School of Community and Environmental Health
Epidemiology: MPH 746
( Second Assignment )
( Type in you name here as First Name , Last Name )
Read the Paper below and answer the following questions. Your answer should be typed in below; and the submitted document should be in Microsoft Word document. The answer for any question should not exceed one paragraph (5-6 lines). The deadline for submission is 11:59 pm EST Nov. 9th, 2022.
( Ellison LF, Morrison HI: Low serum cholesterol concentration and risk of suicide . Epidemiology 2001, 12 (2):168-172. )
QuestionÂ 1Â (Max. 0.5 point)
What is the purpose of the study?
QuestionÂ 2Â (Max. 0.5 point)
What is the study design? What is the exposure? What is the outcome?
QuestionÂ 3Â (Max. 2 points)
How the exposure was measured? How the outcome was measured?
QuestionÂ 4Â (Max. 1.5 points)
From Table II, calculate the Crude Rate Ratio for serum total cholesterol <4.27 mmol/l compared to >5.77 mmol/l. (must show the details of calculation)
QuestionÂ 5Â (Max. 1.5 points)
What is the meaning of this crude Rate Ratio?
QuestionÂ 6Â (Max. 1.5 points)
In Table 3, what is the meaning of age and sex adjusted RR of serum total cholesterol <4.27 mmol/l compared to serum total cholesterol >5.77 mmol/l. Was there confounding by age and sex, why or why not? Is the RR statistically significant? What is the meaning of the 95%CI for the RR?
QuestionÂ 7Â (Max. 0.5 points)
Was the ascertainment of the outcome as complete as possible? Was there a follow chart?
QuestionÂ 8Â (Max. 0.5 points)
The authors stated in the discussion â€œThe possibility of under-ascertainment of suicide deaths is always a concern, although it is probably unlikely that ascertainment varied by serum total cholesterol levelâ€
Explain what the authors meant by their statement.
QuestionÂ 9Â (Max. 0.5 points)
Were those who measured the outcome blinded from the exposure status?
QuestionÂ 10Â (Max. 0.5 points)
Have the exposures been well measured, or is there any random or systematic misclassification?
QuestionÂ 11Â (Max. 5 points)
Do the â€œexposedâ€ differ from the â€œunexposedâ€ with respect to other factors? Have these differences taken into account in the design or analysis? i.e. How the authors dealt with confounding?
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